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MSM for Joint Health: What Methylsulfonylmethane Is, How It Works and Food Sources

The sulfur compound behind flexible joints.

Quick answer

MSM (methylsulfonylmethane) is a natural sulfur-containing compound found in small amounts in plants, fruits, vegetables, grains and the human body. Sulfur is an essential building block of collagen, keratin and glucosamine-related molecules in cartilage, ligaments and tendons. Studies have looked at MSM for supporting joint comfort and physical function and for supporting recovery after exercise. MSM is generally well tolerated; some people notice mild digestive upset. Sulfur-rich foods include eggs, garlic, onions, broccoli, cabbage and legumes.

Key takeaways

MSM is less famous than turmeric or glucosamine, but sulfur plays a quiet, essential role in your joints.

Why sulfur matters

Where sulfur is usedWhy it matters for joints
CollagenStrength of tendons and ligaments
Cartilage moleculesStructure and cushioning
GlutathioneThe body's own antioxidant
Connective tissueFlexibility and repair

What research shows

Joint comfort and function

Small clinical studies have reported that MSM supported joint comfort and physical function compared with placebo.

Exercise recovery

Research in active adults has looked at MSM for reducing muscle soreness and supporting recovery after strenuous exercise.

Combinations

MSM is often paired with glucosamine, chondroitin and botanicals, as in Feilaira, which also contains Boswellia, turmeric and bromelain.

Sulfur-rich foods

Eggs, garlic, onions, leeks, broccoli, cabbage, kale, Brussels sprouts, beans and lentils all provide sulfur compounds that support a joint-friendly diet.

Safety: MSM is generally well tolerated, but some people experience mild bloating or digestive upset. Talk to your doctor before using supplements if you take medication or are pregnant or nursing.

Sources

  1. Butawan M. et al. – "Methylsulfonylmethane: applications and safety of a novel dietary supplement," Nutrients, 2017.
  2. Kim L.S. et al. – "Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial," Osteoarthritis and Cartilage, 2006.
  3. Withee E.D. et al. – "Effects of MSM supplementation on exercise-induced muscle damage," Journal of the International Society of Sports Nutrition, 2017.

Common questions

What is MSM?

Methylsulfonylmethane, a natural sulfur compound found in plants and the body.

How does MSM support joints?

It supplies sulfur for collagen and connective tissue and has been studied for joint comfort.

Which foods contain sulfur?

Eggs, garlic, onions, broccoli, cabbage and legumes.

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